Publications

Asymmetric Synthesis of S(IV) and S(VI) Stereogenic Centers

Xin Zhang * , Fucheng Wang, and Choon-Hong Tan * JACS Au 2023 , 3, 3, 700–714 Abstract Sulfur can form diverse S(IV) and S(VI)...

s2100805

Feb 15, 20241 min read

A chiral pentanidium and pyridinyl-sulphonamide ion pair as an enantioselective organocatalyst for Steglich rearrangement

Ziqi Yang a, Chaoran Xu a, Xianxian Zhou a, Choon Boon Cheong ab, Choon Wee Kee b and Choon-Hong Tan * DOI: 10.1039/D3SC04397E (Edge...

s2100805

Feb 15, 20241 min read

Synthesis of chiral sulfinate esters by asymmetric condensation

Xin Zhang, Esther Cai Xia Ang, Ziqi Yang, Choon Wee Kee and Choon-Hong Tan, Nature, 2022, 604, 298-303 Abstract: Achiral sulfur...

christopherw6

Feb 15, 20221 min read

Pentanidium-Catalyzed Direct Assembly of Vicinal All-Carbon Quaternary Stereocenters

Xu Ban, Yifan Fan, Tuan-Khoa Kha, Richmond Lee, Choon Wee Kee, Zhiyong Jiang and Choon-Hong Tan, CCS Chem. 2021, 3, 2192–2200 Abstract:...

TCHLab

Jun 25, 20211 min read

Stereospecific and stereoconvergent nucleophilicsubstitution reactions at tertiary carbon centers

Xin Zhang, Choon-Hong Tan, Chem, 2021, 7, 1451–1486. Abstract Nucleophilic substitutions such as SN1 and SN2 are fundamental textbook...

TCHLab

Jun 10, 20211 min read

Enantioselective transition metal catalysis directed by chiral cations

Xinyi Ye and Choon-Hong Tan, Chem. Sci., 2021, 12, 533–539. Abstract: Enantioselective transition metal catalysis directed by chiral...

TCHLab

Dec 11, 20201 min read

Enantioselective Addition-Alkylation of α,β-Unsaturated Carbonyls via BG Silicate Ion Pair Catalysis

Abstract: Silicon hydrides, alkynylsilanes, and alkoxylsilanes were activated by fluoride in the presence of bisguanidinium catalyst to...

TCHLab

Oct 29, 20201 min read

Preparation of Asymmetric PTC, tBu-Bisguaninidium Catalyst

Full Text Available at: http://orgsyn.org/Content/pdfs/procedures/v97p0274.pdf

TCHLab

Sep 17, 20201 min read

Golden Jubilee of Singapore National Institute of Chemistry (1970–2020)

Abstract This year Singapore National Institute of Chemistry (SNIC) is celebrating its golden jubilee (1970–2020). Wiley‐VCH has been a...

TCHLab

Aug 16, 20201 min read

K and DK Resolution of Racemic Tertiary Bromides by Pentanidium-Catalyzed PT Azidation

Abstract: We have developed a method to afford enantiomerically enriched tertiary azides and bromides through pentanidium‐catalyzed...

TCHLab

May 17, 20201 min read

BG-Catalyzed Epoxidation of Allylic and Homoallylic Amines under Phase Transfer Conditions

Kek Foo Chin, Xinyi Ye, Yongxin Li, Richmond Lee, Adil M. Kabylda, Dasheng Leow, Xin Zhang, Esther Cai Xia Ang, and Choon-Hong Tan...

TCHLab

Jan 9, 20201 min read

Recent Advances in Chiral Guanidine-Catalyzed Enantioselective Reactions

Abstract Chiral guanidines have been widely used as Brønsted base catalysts and phase transfer catalysts in enantioselective reactions....

TCHLab

Nov 4, 20191 min read

Discovery of a New Class of Organic Reactions

X. Zhang, J. Ren, S. M. Tan, D. Tan, R. Lee, and C.-H. Tan, An enantioconvergent halogenophilic nucleophilic substitution (SN2X)...

TCHLab

Apr 9, 20192 min read

An enantioconvergent halogenophilic nucleophilic substitution (SN2X) reaction

Zhang, Xin; Ren, Jingyun; Tan, Siu Min; Tan, Davin; Lee, Richmond; Tan, Choon-Hong Science (New York, N.Y.), 2019, 363, 400-404 Abstract:...

TCHLab

Jan 25, 20191 min read

Hyperfast Water Transport through Biomimetic Nanochannels from Peptide‐Attached (pR)‐pillar[5]arene

Li, Qing; Li, Xuesong; Ning, Lulu; Tan, Choon-Hong; Mu, Yuguang; Wang, Rong Small, 2019, 15(6) Abstract: Synthetic water channels offer...

TCHLab

Jan 13, 20191 min read

Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

Fong, July; Mortensen, Kim T; Nørskov, Amalie; Qvortrup, Katrine; Yang, Liang; Tan, Choon Hong; Nielsen, Thomas E; Givskov, Michael...

TCHLab

Jan 7, 20191 min read

Guanidine-Copper Complex Catalyzed Allylic Borylation for the

Enantioconvergent Synthesis of Tertiary Cyclic Allylboronates Ge, Yicen; Cui, Xi-Yang; Tan, Siu Min; Jiang, Huan; Ren, Jingyun; Lee,...

TCHLab

Jan 7, 20191 min read

Development of highly-efficient ZIF-8@PDMS/PVDF nanofibrous composite membrane

for phenol removal in aqueous-aqueous membrane extractive process Jin, Meng-Yi; Lin, Yuqing; Liao, Yuan; Tan, Choon-Hong; Wang, Rong...

TCHLab

Dec 15, 20181 min read

Repurposing the anticancer drug cisplatin with the aim of developing novel

Pseudomonas aeruginosa infection control agents Yuan, Mingjun; Chua, Song Lin; Liu, Yang; Drautz-Moses, Daniela I; Yam, Joey Kuok Hoong;...

TCHLab

Dec 14, 20181 min read

Asymmetric Brook Rearrangement

Nicholas Lee, Prof. Choon‐Hong Tan and Dr. Dasheng Leow Asian Journal of Organic Chemistry, 2019, 8, 25-31 Abstract: Although the Brook...

TCHLab

Nov 13, 20181 min read

(Guanidine)copper Complex-Catalyzed Enantioselective Dynamic Kinetic Allylic Alkynylation

under Biphasic Condition Xi-Yang Cui, Yicen Ge, Siu Min Tan, Huan Jiang, Davin Tan, Yunpeng Lu, Richmond Lee , and Choon-Hong Tan J. Am....

TCHLab

Jun 12, 20181 min read

Cancer-targeted design of bioresponsive prodrug with enhanced cellular uptake to

achieve precise cancer therapy Liang, Yuanwei; Huang, Wei; Zeng, Delong; Huang, Xiaoting; Chan, Leung; Mei, Chaoming; Feng, Pengju; Tan,...

TCHLab

Jun 5, 20181 min read

Development of high performance nanofibrous composite membranes by

optimizing polydimethylsiloxane architectures for phenol transport Meng-Yi Jin, Yuan Liao, Choon-Hong Tan and Rong Wang Journal of...

TCHLab

Mar 1, 20181 min read

Enantioselective 1,2-Anionotropic Rearrangement of Acylsilane

through a Bisguanidinium Silicate Ion Pair Weidi Cao, Davin Tan, Richmond Lee and Choon-Hong Tan J. Am. Chem. Soc., 2018, 140, 1952-1955...

TCHLab

Jan 11, 20181 min read

Aerobic Oxidation of Benzylic sp3 C−H Bonds

through Cooperative Visible‐Light Photoredox Catalysis of N‐Hydroxyimide and Dicyanopyrazine Xinfei Liu, Lu Lin, Xinyi Ye, Choon‐Hong Tan...

TCHLab

Nov 7, 20171 min read

Organocatalytic Enantioselective Protonation for Photoreduction of

Activated Ketones and Ketimines Induced by Visible Light Lu Lin, Xiangbin Bai, Xinyi Ye, Xiaowei Zhao, Choon‐Hong Tan, and Zhiyong Jiang....

TCHLab

Sep 16, 20171 min read

Recent Advances in Enantioselective Brønsted Base Organocatalytic Reactions

Bo Teng, Wei Chun Lim and Choon-Hong Tan Synlett., 2017, 28, 1272-1277 Abstract: Enantioselective Brønsted base catalyzed reactions have...

TCHLab

May 23, 20171 min read

Phase-Transfer and Ion-Pairing Catalysis of Pentanidiums and Bisguanidiniums

Lili Zong and Choon-Hong Tan Acc. Chem. Res. 2017, 50, 842−856 Abstract: Catalysts accelerate biological processes and organic reactions...

TCHLab

Apr 5, 20172 min read

Preparation of Polydimethylsiloxane–Polyvinylidene Fluoride Composite Membranes for

Phenol Removal in Extractive Membrane Bioreactor Meng-Yi Jin, Yuan Liao, Chun Heng Loh, Choon-Hong Tan and Rong Wang Ind. Eng. Chem....

TCHLab

Mar 9, 20172 min read

Mechanistic insights for the photoredox organocatalytic fluorination of aliphatic carbons

by anthraquinone using time-resolved and DFT studies Kee, J. W.; Shao, H.; Kee, C. W.; Lu, Y.; Soo, H. S.; Tan, C.-H Catalysis Science &...

TCHLab

Jan 20, 20171 min read

Disulfide Bond-Containing Ajoene Analogues As

Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa Fong, July; Yuan, Mingjun;...

TCHLab

Dec 15, 20161 min read

Bisguanidinium dinuclear oxodiperoxomolybdosulfate ion pair-catalyzed enantioselective sulfoxidation

Lili Zong, Chao Wang, Adhitya Mangala Putra Moeljadi, Xinyi Ye, Rakesh Ganguly, Yongxin Li, Hajime Hirao and Choon-Hong Tan Nature Comms,...

TCHLab

Nov 21, 20161 min read

Highly chemo-, enantio-, and diastereoselective [4 + 2] cycloaddition

of 5H-thiazole-4-ones with N-itaconimides Shuai Qiu, Choon-Hong Tan and Zhiyong Jiang Beilstein J. Org. Chem., 2016, 12, 2293 - 2297...

TCHLab

Nov 1, 20161 min read

Visible light photocatalysis in chemoselective functionalization of

C(sp3)-H bonds enabled by organic dyes Guo Wei, Chanbasha Basheer, Choon-Hong Tan and ZhiyongJiang Tetrahedron Letters, 2016, 57, 3801 -...

TCHLab

Aug 24, 20161 min read

Guanidine-catalyzed asymmetric Strecker reaction:

modes of activation and origin of stereoselectivity Xue, Hansong; Tan, Choon-Hong and Wong, Ming Wah Canadian Journal of Chemistry 2016,...

TCHLab

Aug 22, 20161 min read

Pentanidium- and Bisguanidinium-Catalyzed Enantioselective Alkylations

Using Silylamide as Brønsted Probase Bo Teng, Wenchao Chen, Shen Dong, Choon Wee Kee, Dhika Aditya Gandamana, Lili Zong and Choon-Hong...

TCHLab

Jul 22, 20161 min read

Enantioselective Aerobic Oxidative C(sp3)–H Olefination of Amines via

Cooperative Photoredox and Asymmetric Catalysis Guo Wei, Chenhao Zhang, Filip Bureš, Xinyi Ye, Choon-Hong Tan, Zhiyong Jiang ACS...

TCHLab

May 9, 20161 min read

Enantioselective Sulfoxidation Catalyzed by a Bisguanidinium Diphosphatobisperoxotungstate Ion Pair

Xinyi Ye, Adhitya Mangala Putra Moeljadi, Kek Foo Chin, Prof. Dr. Hajime Hirao, Dr. Lili Zong and Prof. Dr. Choon‐Hong Tan Angew. Chem....

TCHLab

May 6, 20161 min read

Chiral Bicyclic Guanidine-Catalyzed Enantioselective Sulfenylation of

Oxindoles and Benzofuran-2(3H)-ones Lisha Huang, Jiangtao Li, Yan Zhao, Xinyi Ye, Yang Liu, Lin Yan, Choon-Hong Tan, Hongjun Liu and...

TCHLab

Aug 6, 20151 min read

Enantioselective Oxidation of Alkenes with KMnO4 Catalyzed by Chiral Dicationic Bisguanidinium

Chao Wang, Lili Zong and Choon-Hong Tan J. Am. Chem. Soc., 2015, 137, 10677–10682 Abstract: Chiral anion-controlled ion-pairing catalysis...

TCHLab

Aug 3, 20151 min read

Enantioselective Synthesis of Quaternary Carbon Stereocenters:

Addition of 3-Substituted Oxindoles to Vinyl Sulfone Catalyzed with Pentanidiums Dr. Lili Zong, Shubo Du, Kek Foo Chin, Dr. Chao Wang and...

TCHLab

Jul 15, 20151 min read

Enantioselective Synthesis of Dialkylated α-Hydroxy Carboxylic Acids through Asymmetric PTC

(PTC = Phase-Transfer Catalysis) Shaobo Duan, Sanliang Li, Xinyi Ye, Nuan-Nuan Du, Choon-Hong Tan and Zhiyong Jiang The Journal of...

TCHLab

Jul 7, 20151 min read

Mechanistic Insights into Bicyclic Guanidine-Catalyzed Reactions

from Microscopic and Macroscopic Perspectives Hansong Xue, Danfeng Jiang, Huan Jiang, Choon Wee Kee, Hajime Hirao, Takahiro Nishimura,...

TCHLab

May 14, 20151 min read

Bicyclic Guanidine Catalyzed Asymmetric Tandem Isomerization Intramolecular‐Diels–Alder Reaction:

The First Catalytic Enantioselective Total Synthesis of (+)‐alpha‐Yohimbine Dr. Wei Feng, Danfeng Jiang, Dr. Choon‐Wee Kee, Dr. Hongjun...

TCHLab

Apr 30, 20151 min read

Asymmetric Michael Addition of 5 H-Oxazol-4-ones to Vinyl Sulfones:

Stereoselective Synthesis of Monofluorinated Analogs of 2‐Tertiary Hydroxyl‐3‐Methyl‐Substituted Carboxylic Acidl Derivatives Qian Liu,...

TCHLab

Oct 24, 20141 min read

Selective Fluorination of Unactivated C-H bond via organo-photocatalysis

Choon Wee Kee, Ke Min Chan, Prof. Dr. Ming Wah Wong and Prof. Dr. Choon‐Hong Tan Chemical Communications, 2014, 50, 8211 – 8214 Abstract:...

TCHLab

Oct 18, 20141 min read

Selective Bromination of sp3 C-H Bonds by Organophotoredox Catalysis

Choon Wee Kee, Ke Min Chan, Prof. Dr. Ming Wah Wong and Prof. Dr. Choon‐Hong Tan Asian Journal of Organic Chemistry, 2014, 3, 536 – 544...

TCHLab

Oct 18, 20141 min read

Catalytic Enantioselective Alkylation of Sulfenate Anions to Chiral Heterocyclic Sulfoxides

Using Halogenated Pentanidium Salts Lili Zong, Xu Ban, Choon Wee Kee and Prof. Dr. Choon‐Hong Tan Angewandte Chemie International...

TCHLab

Sep 10, 20141 min read

Utilizing hydrogen sulfide as a novel anti-cancer agent

by targeting cancer glycolysis and pH imbalance Z.-W. Lee, X.-Y. Teo, Evon Y.-W. Tay, C.-H. Tan, T. Hagen, P. K. Moore and L.-W. Deng...

TCHLab

Jul 2, 20141 min read

Halogen-Bonding-Induced Hydrogen Transfer to C=N Bond with Hantzsch Ester

Wei He, Yi-Cen Ge and Choon-Hong Tan Organic Letters, 2014, 16, 3244 – 3247 Abstract: Several bidentate dihydroimidazolines were prepared...

TCHLab

Jun 6, 20141 min read