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Publications
Asymmetric Synthesis of S(IV) and S(VI) Stereogenic Centers
Xin Zhang * , Fucheng Wang, and Choon-Hong Tan * JACS Au 2023 , 3, 3, 700–714 Abstract Sulfur can form diverse S(IV) and S(VI)...
s2100805
Feb 15, 20241 min read
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A chiral pentanidium and pyridinyl-sulphonamide ion pair as an enantioselective organocatalyst for Steglich rearrangement
Ziqi Yang a, Chaoran Xu a, Xianxian Zhou a, Choon Boon Cheong ab, Choon Wee Kee b and Choon-Hong Tan * DOI: 10.1039/D3SC04397E (Edge...
s2100805
Feb 15, 20241 min read
207 views
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Synthesis of chiral sulfinate esters by asymmetric condensation
Xin Zhang, Esther Cai Xia Ang, Ziqi Yang, Choon Wee Kee and Choon-Hong Tan, Nature, 2022, 604, 298-303 Abstract: Achiral sulfur...
christopherw6
Feb 15, 20221 min read
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Pentanidium-Catalyzed Direct Assembly of Vicinal All-Carbon Quaternary Stereocenters
Xu Ban, Yifan Fan, Tuan-Khoa Kha, Richmond Lee, Choon Wee Kee, Zhiyong Jiang and Choon-Hong Tan, CCS Chem. 2021, 3, 2192–2200 Abstract:...
TCHLab
Jun 25, 20211 min read
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Stereospecific and stereoconvergent nucleophilicsubstitution reactions at tertiary carbon centers
Xin Zhang, Choon-Hong Tan, Chem, 2021, 7, 1451–1486. Abstract Nucleophilic substitutions such as SN1 and SN2 are fundamental textbook...
TCHLab
Jun 10, 20211 min read
621 views
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Enantioselective transition metal catalysis directed by chiral cations
Xinyi Ye and Choon-Hong Tan, Chem. Sci., 2021, 12, 533–539. Abstract: Enantioselective transition metal catalysis directed by chiral...
TCHLab
Dec 11, 20201 min read
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Enantioselective Addition-Alkylation of α,β-Unsaturated Carbonyls via BG Silicate Ion Pair Catalysis
Abstract: Silicon hydrides, alkynylsilanes, and alkoxylsilanes were activated by fluoride in the presence of bisguanidinium catalyst to...
TCHLab
Oct 29, 20201 min read
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Preparation of Asymmetric PTC, tBu-Bisguaninidium Catalyst
Full Text Available at: http://orgsyn.org/Content/pdfs/procedures/v97p0274.pdf
TCHLab
Sep 17, 20201 min read
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Golden Jubilee of Singapore National Institute of Chemistry (1970–2020)
Abstract This year Singapore National Institute of Chemistry (SNIC) is celebrating its golden jubilee (1970–2020). Wiley‐VCH has been a...
TCHLab
Aug 16, 20201 min read
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K and DK Resolution of Racemic Tertiary Bromides by Pentanidium-Catalyzed PT Azidation
Abstract: We have developed a method to afford enantiomerically enriched tertiary azides and bromides through pentanidium‐catalyzed...
TCHLab
May 17, 20201 min read
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BG-Catalyzed Epoxidation of Allylic and Homoallylic Amines under Phase Transfer Conditions
Kek Foo Chin, Xinyi Ye, Yongxin Li, Richmond Lee, Adil M. Kabylda, Dasheng Leow, Xin Zhang, Esther Cai Xia Ang, and Choon-Hong Tan...
TCHLab
Jan 9, 20201 min read
390 views
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Recent Advances in Chiral Guanidine-Catalyzed Enantioselective Reactions
Abstract Chiral guanidines have been widely used as Brønsted base catalysts and phase transfer catalysts in enantioselective reactions....
TCHLab
Nov 4, 20191 min read
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Discovery of a New Class of Organic Reactions
X. Zhang, J. Ren, S. M. Tan, D. Tan, R. Lee, and C.-H. Tan, An enantioconvergent halogenophilic nucleophilic substitution (SN2X)...
TCHLab
Apr 9, 20192 min read
782 views
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An enantioconvergent halogenophilic nucleophilic substitution (SN2X) reaction
Zhang, Xin; Ren, Jingyun; Tan, Siu Min; Tan, Davin; Lee, Richmond; Tan, Choon-Hong Science (New York, N.Y.), 2019, 363, 400-404 Abstract:...
TCHLab
Jan 25, 20191 min read
469 views
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![Hyperfast Water Transport through Biomimetic Nanochannels from Peptide‐Attached (pR)‐pillar[5]arene](https://static.wixstatic.com/media/43e1f5_ef97a09742e44077b6b3328324c98622~mv2.png/v1/fill/w_367,h_232,fp_0.50_0.50,q_95,enc_avif,quality_auto/43e1f5_ef97a09742e44077b6b3328324c98622~mv2.webp)
Hyperfast Water Transport through Biomimetic Nanochannels from Peptide‐Attached (pR)‐pillar[5]arene
Li, Qing; Li, Xuesong; Ning, Lulu; Tan, Choon-Hong; Mu, Yuguang; Wang, Rong Small, 2019, 15(6) Abstract: Synthetic water channels offer...
TCHLab
Jan 13, 20191 min read
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Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa
Fong, July; Mortensen, Kim T; Nørskov, Amalie; Qvortrup, Katrine; Yang, Liang; Tan, Choon Hong; Nielsen, Thomas E; Givskov, Michael...
TCHLab
Jan 7, 20191 min read
86 views
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Guanidine-Copper Complex Catalyzed Allylic Borylation for the
Enantioconvergent Synthesis of Tertiary Cyclic Allylboronates Ge, Yicen; Cui, Xi-Yang; Tan, Siu Min; Jiang, Huan; Ren, Jingyun; Lee,...
TCHLab
Jan 7, 20191 min read
153 views
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Development of highly-efficient ZIF-8@PDMS/PVDF nanofibrous composite membrane
for phenol removal in aqueous-aqueous membrane extractive process Jin, Meng-Yi; Lin, Yuqing; Liao, Yuan; Tan, Choon-Hong; Wang, Rong...
TCHLab
Dec 15, 20181 min read
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Repurposing the anticancer drug cisplatin with the aim of developing novel
Pseudomonas aeruginosa infection control agents Yuan, Mingjun; Chua, Song Lin; Liu, Yang; Drautz-Moses, Daniela I; Yam, Joey Kuok Hoong;...
TCHLab
Dec 14, 20181 min read
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Asymmetric Brook Rearrangement
Nicholas Lee, Prof. Choon‐Hong Tan and Dr. Dasheng Leow Asian Journal of Organic Chemistry, 2019, 8, 25-31 Abstract: Although the Brook...
TCHLab
Nov 13, 20181 min read
94 views
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(Guanidine)copper Complex-Catalyzed Enantioselective Dynamic Kinetic Allylic Alkynylation
under Biphasic Condition Xi-Yang Cui, Yicen Ge, Siu Min Tan, Huan Jiang, Davin Tan, Yunpeng Lu, Richmond Lee , and Choon-Hong Tan J. Am....
TCHLab
Jun 12, 20181 min read
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Cancer-targeted design of bioresponsive prodrug with enhanced cellular uptake to
achieve precise cancer therapy Liang, Yuanwei; Huang, Wei; Zeng, Delong; Huang, Xiaoting; Chan, Leung; Mei, Chaoming; Feng, Pengju; Tan,...
TCHLab
Jun 5, 20181 min read
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Development of high performance nanofibrous composite membranes by
optimizing polydimethylsiloxane architectures for phenol transport Meng-Yi Jin, Yuan Liao, Choon-Hong Tan and Rong Wang Journal of...
TCHLab
Mar 1, 20181 min read
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Enantioselective 1,2-Anionotropic Rearrangement of Acylsilane
through a Bisguanidinium Silicate Ion Pair Weidi Cao, Davin Tan, Richmond Lee and Choon-Hong Tan J. Am. Chem. Soc., 2018, 140, 1952-1955...
TCHLab
Jan 11, 20181 min read
83 views
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Aerobic Oxidation of Benzylic sp3 C−H Bonds
through Cooperative Visible‐Light Photoredox Catalysis of N‐Hydroxyimide and Dicyanopyrazine Xinfei Liu, Lu Lin, Xinyi Ye, Choon‐Hong Tan...
TCHLab
Nov 7, 20171 min read
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Organocatalytic Enantioselective Protonation for Photoreduction of
Activated Ketones and Ketimines Induced by Visible Light Lu Lin, Xiangbin Bai, Xinyi Ye, Xiaowei Zhao, Choon‐Hong Tan, and Zhiyong Jiang....
TCHLab
Sep 16, 20171 min read
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Recent Advances in Enantioselective Brønsted Base Organocatalytic Reactions
Bo Teng, Wei Chun Lim and Choon-Hong Tan Synlett., 2017, 28, 1272-1277 Abstract: Enantioselective Brønsted base catalyzed reactions have...
TCHLab
May 23, 20171 min read
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Phase-Transfer and Ion-Pairing Catalysis of Pentanidiums and Bisguanidiniums
Lili Zong and Choon-Hong Tan Acc. Chem. Res. 2017, 50, 842−856 Abstract: Catalysts accelerate biological processes and organic reactions...
TCHLab
Apr 5, 20172 min read
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Preparation of Polydimethylsiloxane–Polyvinylidene Fluoride Composite Membranes for
Phenol Removal in Extractive Membrane Bioreactor Meng-Yi Jin, Yuan Liao, Chun Heng Loh, Choon-Hong Tan and Rong Wang Ind. Eng. Chem....
TCHLab
Mar 9, 20172 min read
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Mechanistic insights for the photoredox organocatalytic fluorination of aliphatic carbons
by anthraquinone using time-resolved and DFT studies Kee, J. W.; Shao, H.; Kee, C. W.; Lu, Y.; Soo, H. S.; Tan, C.-H Catalysis Science &...
TCHLab
Jan 20, 20171 min read
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Disulfide Bond-Containing Ajoene Analogues As
Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa Fong, July; Yuan, Mingjun;...
TCHLab
Dec 15, 20161 min read
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Bisguanidinium dinuclear oxodiperoxomolybdosulfate ion pair-catalyzed enantioselective sulfoxidation
Lili Zong, Chao Wang, Adhitya Mangala Putra Moeljadi, Xinyi Ye, Rakesh Ganguly, Yongxin Li, Hajime Hirao and Choon-Hong Tan Nature Comms,...
TCHLab
Nov 21, 20161 min read
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![Highly chemo-, enantio-, and diastereoselective [4 + 2] cycloaddition](https://static.wixstatic.com/media/43e1f5_a8425633278145dabb5182ce8092afb6~mv2.jpg/v1/fill/w_367,h_230,fp_0.50_0.50,q_90,enc_avif,quality_auto/43e1f5_a8425633278145dabb5182ce8092afb6~mv2.webp)
Highly chemo-, enantio-, and diastereoselective [4 + 2] cycloaddition
of 5H-thiazole-4-ones with N-itaconimides Shuai Qiu, Choon-Hong Tan and Zhiyong Jiang Beilstein J. Org. Chem., 2016, 12, 2293 - 2297...
TCHLab
Nov 1, 20161 min read
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Visible light photocatalysis in chemoselective functionalization of
C(sp3)-H bonds enabled by organic dyes Guo Wei, Chanbasha Basheer, Choon-Hong Tan and ZhiyongJiang Tetrahedron Letters, 2016, 57, 3801 -...
TCHLab
Aug 24, 20161 min read
14 views
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Guanidine-catalyzed asymmetric Strecker reaction:
modes of activation and origin of stereoselectivity Xue, Hansong; Tan, Choon-Hong and Wong, Ming Wah Canadian Journal of Chemistry 2016,...
TCHLab
Aug 22, 20161 min read
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Pentanidium- and Bisguanidinium-Catalyzed Enantioselective Alkylations
Using Silylamide as Brønsted Probase Bo Teng, Wenchao Chen, Shen Dong, Choon Wee Kee, Dhika Aditya Gandamana, Lili Zong and Choon-Hong...
TCHLab
Jul 22, 20161 min read
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Enantioselective Aerobic Oxidative C(sp3)–H Olefination of Amines via
Cooperative Photoredox and Asymmetric Catalysis Guo Wei, Chenhao Zhang, Filip Bureš, Xinyi Ye, Choon-Hong Tan, Zhiyong Jiang ACS...
TCHLab
May 9, 20161 min read
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Enantioselective Sulfoxidation Catalyzed by a Bisguanidinium Diphosphatobisperoxotungstate Ion Pair
Xinyi Ye, Adhitya Mangala Putra Moeljadi, Kek Foo Chin, Prof. Dr. Hajime Hirao, Dr. Lili Zong and Prof. Dr. Choon‐Hong Tan Angew. Chem....
TCHLab
May 6, 20161 min read
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Chiral Bicyclic Guanidine-Catalyzed Enantioselective Sulfenylation of
Oxindoles and Benzofuran-2(3H)-ones Lisha Huang, Jiangtao Li, Yan Zhao, Xinyi Ye, Yang Liu, Lin Yan, Choon-Hong Tan, Hongjun Liu and...
TCHLab
Aug 6, 20151 min read
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Enantioselective Oxidation of Alkenes with KMnO4 Catalyzed by Chiral Dicationic Bisguanidinium
Chao Wang, Lili Zong and Choon-Hong Tan J. Am. Chem. Soc., 2015, 137, 10677–10682 Abstract: Chiral anion-controlled ion-pairing catalysis...
TCHLab
Aug 3, 20151 min read
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Enantioselective Synthesis of Quaternary Carbon Stereocenters:
Addition of 3-Substituted Oxindoles to Vinyl Sulfone Catalyzed with Pentanidiums Dr. Lili Zong, Shubo Du, Kek Foo Chin, Dr. Chao Wang and...
TCHLab
Jul 15, 20151 min read
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Enantioselective Synthesis of Dialkylated α-Hydroxy Carboxylic Acids through Asymmetric PTC
(PTC = Phase-Transfer Catalysis) Shaobo Duan, Sanliang Li, Xinyi Ye, Nuan-Nuan Du, Choon-Hong Tan and Zhiyong Jiang The Journal of...
TCHLab
Jul 7, 20151 min read
34 views
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Mechanistic Insights into Bicyclic Guanidine-Catalyzed Reactions
from Microscopic and Macroscopic Perspectives Hansong Xue, Danfeng Jiang, Huan Jiang, Choon Wee Kee, Hajime Hirao, Takahiro Nishimura,...
TCHLab
May 14, 20151 min read
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Bicyclic Guanidine Catalyzed Asymmetric Tandem Isomerization Intramolecular‐Diels–Alder Reaction:
The First Catalytic Enantioselective Total Synthesis of (+)‐alpha‐Yohimbine Dr. Wei Feng, Danfeng Jiang, Dr. Choon‐Wee Kee, Dr. Hongjun...
TCHLab
Apr 30, 20151 min read
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Asymmetric Michael Addition of 5 H-Oxazol-4-ones to Vinyl Sulfones:
Stereoselective Synthesis of Monofluorinated Analogs of 2‐Tertiary Hydroxyl‐3‐Methyl‐Substituted Carboxylic Acidl Derivatives Qian Liu,...
TCHLab
Oct 24, 20141 min read
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Selective Fluorination of Unactivated C-H bond via organo-photocatalysis
Choon Wee Kee, Ke Min Chan, Prof. Dr. Ming Wah Wong and Prof. Dr. Choon‐Hong Tan Chemical Communications, 2014, 50, 8211 – 8214 Abstract:...
TCHLab
Oct 18, 20141 min read
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Selective Bromination of sp3 C-H Bonds by Organophotoredox Catalysis
Choon Wee Kee, Ke Min Chan, Prof. Dr. Ming Wah Wong and Prof. Dr. Choon‐Hong Tan Asian Journal of Organic Chemistry, 2014, 3, 536 – 544...
TCHLab
Oct 18, 20141 min read
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Catalytic Enantioselective Alkylation of Sulfenate Anions to Chiral Heterocyclic Sulfoxides
Using Halogenated Pentanidium Salts Lili Zong, Xu Ban, Choon Wee Kee and Prof. Dr. Choon‐Hong Tan Angewandte Chemie International...
TCHLab
Sep 10, 20141 min read
47 views
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Utilizing hydrogen sulfide as a novel anti-cancer agent
by targeting cancer glycolysis and pH imbalance Z.-W. Lee, X.-Y. Teo, Evon Y.-W. Tay, C.-H. Tan, T. Hagen, P. K. Moore and L.-W. Deng...
TCHLab
Jul 2, 20141 min read
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Halogen-Bonding-Induced Hydrogen Transfer to C=N Bond with Hantzsch Ester
Wei He, Yi-Cen Ge and Choon-Hong Tan Organic Letters, 2014, 16, 3244 – 3247 Abstract: Several bidentate dihydroimidazolines were prepared...
TCHLab
Jun 6, 20141 min read
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