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Publications

s2100805
Feb 15, 20241 min read
Asymmetric Synthesis of S(IV) and S(VI) Stereogenic Centers
Xin Zhang * , Fucheng Wang, and Choon-Hong Tan * JACS Au 2023 , 3, 3, 700–714 Abstract Sulfur can form diverse S(IV) and S(VI)...
201 views0 comments

s2100805
Feb 15, 20241 min read
A chiral pentanidium and pyridinyl-sulphonamide ion pair as an enantioselective organocatalyst for Steglich rearrangement
Ziqi Yang a, Chaoran Xu a, Xianxian Zhou a, Choon Boon Cheong ab, Choon Wee Kee b and Choon-Hong Tan * DOI: 10.1039/D3SC04397E (Edge...
182 views0 comments


christopherw6
Feb 15, 20221 min read
Synthesis of chiral sulfinate esters by asymmetric condensation
Xin Zhang, Esther Cai Xia Ang, Ziqi Yang, Choon Wee Kee and Choon-Hong Tan, Nature, 2022, 604, 298-303 Abstract: Achiral sulfur...
776 views0 comments


TCHLab
Jun 25, 20211 min read
Pentanidium-Catalyzed Direct Assembly of Vicinal All-Carbon Quaternary Stereocenters
Xu Ban, Yifan Fan, Tuan-Khoa Kha, Richmond Lee, Choon Wee Kee, Zhiyong Jiang and Choon-Hong Tan, CCS Chem. 2021, 3, 2192–2200 Abstract:...
443 views0 comments


TCHLab
Jun 10, 20211 min read
Stereospecific and stereoconvergent nucleophilicsubstitution reactions at tertiary carbon centers
Xin Zhang, Choon-Hong Tan, Chem, 2021, 7, 1451–1486. Abstract Nucleophilic substitutions such as SN1 and SN2 are fundamental textbook...
609 views0 comments

TCHLab
Dec 11, 20201 min read
Enantioselective transition metal catalysis directed by chiral cations
Xinyi Ye and Choon-Hong Tan, Chem. Sci., 2021, 12, 533–539. Abstract: Enantioselective transition metal catalysis directed by chiral...
186 views0 comments

TCHLab
Oct 29, 20201 min read
Enantioselective Addition-Alkylation of α,β-Unsaturated Carbonyls via BG Silicate Ion Pair Catalysis
Abstract: Silicon hydrides, alkynylsilanes, and alkoxylsilanes were activated by fluoride in the presence of bisguanidinium catalyst to...
270 views0 comments

TCHLab
Sep 17, 20201 min read
Preparation of Asymmetric PTC, tBu-Bisguaninidium Catalyst
Full Text Available at: http://orgsyn.org/Content/pdfs/procedures/v97p0274.pdf
177 views0 comments

TCHLab
Aug 16, 20201 min read
Golden Jubilee of Singapore National Institute of Chemistry (1970–2020)
Abstract This year Singapore National Institute of Chemistry (SNIC) is celebrating its golden jubilee (1970–2020). Wiley‐VCH has been a...
109 views0 comments

TCHLab
May 17, 20201 min read
K and DK Resolution of Racemic Tertiary Bromides by Pentanidium-Catalyzed PT Azidation
Abstract: We have developed a method to afford enantiomerically enriched tertiary azides and bromides through pentanidium‐catalyzed...
209 views0 comments

TCHLab
Jan 9, 20201 min read
BG-Catalyzed Epoxidation of Allylic and Homoallylic Amines under Phase Transfer Conditions
Kek Foo Chin, Xinyi Ye, Yongxin Li, Richmond Lee, Adil M. Kabylda, Dasheng Leow, Xin Zhang, Esther Cai Xia Ang, and Choon-Hong Tan...
384 views0 comments

TCHLab
Nov 4, 20191 min read
Recent Advances in Chiral Guanidine-Catalyzed Enantioselective Reactions
Abstract Chiral guanidines have been widely used as Brønsted base catalysts and phase transfer catalysts in enantioselective reactions....
272 views0 comments

TCHLab
Apr 9, 20192 min read
Discovery of a New Class of Organic Reactions
X. Zhang, J. Ren, S. M. Tan, D. Tan, R. Lee, and C.-H. Tan, An enantioconvergent halogenophilic nucleophilic substitution (SN2X)...
767 views0 comments

TCHLab
Jan 25, 20191 min read
An enantioconvergent halogenophilic nucleophilic substitution (SN2X) reaction
Zhang, Xin; Ren, Jingyun; Tan, Siu Min; Tan, Davin; Lee, Richmond; Tan, Choon-Hong Science (New York, N.Y.), 2019, 363, 400-404 Abstract:...
467 views1 comment
![Hyperfast Water Transport through Biomimetic Nanochannels from Peptide‐Attached (pR)‐pillar[5]arene](https://static.wixstatic.com/media/43e1f5_ef97a09742e44077b6b3328324c98622~mv2.png/v1/fill/w_367,h_232,fp_0.50_0.50,q_95,enc_auto/43e1f5_ef97a09742e44077b6b3328324c98622~mv2.webp)
TCHLab
Jan 13, 20191 min read
Hyperfast Water Transport through Biomimetic Nanochannels from Peptide‐Attached (pR)‐pillar[5]arene
Li, Qing; Li, Xuesong; Ning, Lulu; Tan, Choon-Hong; Mu, Yuguang; Wang, Rong Small, 2019, 15(6) Abstract: Synthetic water channels offer...
71 views0 comments

TCHLab
Jan 7, 20191 min read
Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa
Fong, July; Mortensen, Kim T; Nørskov, Amalie; Qvortrup, Katrine; Yang, Liang; Tan, Choon Hong; Nielsen, Thomas E; Givskov, Michael...
85 views0 comments

TCHLab
Jan 7, 20191 min read
Guanidine-Copper Complex Catalyzed Allylic Borylation for the
Enantioconvergent Synthesis of Tertiary Cyclic Allylboronates Ge, Yicen; Cui, Xi-Yang; Tan, Siu Min; Jiang, Huan; Ren, Jingyun; Lee,...
151 views0 comments


TCHLab
Dec 15, 20181 min read
Development of highly-efficient ZIF-8@PDMS/PVDF nanofibrous composite membrane
for phenol removal in aqueous-aqueous membrane extractive process Jin, Meng-Yi; Lin, Yuqing; Liao, Yuan; Tan, Choon-Hong; Wang, Rong...
67 views0 comments

TCHLab
Dec 14, 20181 min read
Repurposing the anticancer drug cisplatin with the aim of developing novel
Pseudomonas aeruginosa infection control agents Yuan, Mingjun; Chua, Song Lin; Liu, Yang; Drautz-Moses, Daniela I; Yam, Joey Kuok Hoong;...
35 views0 comments

TCHLab
Nov 13, 20181 min read
Asymmetric Brook Rearrangement
Nicholas Lee, Prof. Choon‐Hong Tan and Dr. Dasheng Leow Asian Journal of Organic Chemistry, 2019, 8, 25-31 Abstract: Although the Brook...
90 views0 comments

TCHLab
Jun 12, 20181 min read
(Guanidine)copper Complex-Catalyzed Enantioselective Dynamic Kinetic Allylic Alkynylation
under Biphasic Condition Xi-Yang Cui, Yicen Ge, Siu Min Tan, Huan Jiang, Davin Tan, Yunpeng Lu, Richmond Lee , and Choon-Hong Tan J. Am....
66 views0 comments

TCHLab
Jun 5, 20181 min read
Cancer-targeted design of bioresponsive prodrug with enhanced cellular uptake to
achieve precise cancer therapy Liang, Yuanwei; Huang, Wei; Zeng, Delong; Huang, Xiaoting; Chan, Leung; Mei, Chaoming; Feng, Pengju; Tan,...
50 views0 comments

TCHLab
Mar 1, 20181 min read
Development of high performance nanofibrous composite membranes by
optimizing polydimethylsiloxane architectures for phenol transport Meng-Yi Jin, Yuan Liao, Choon-Hong Tan and Rong Wang Journal of...
13 views0 comments


TCHLab
Jan 11, 20181 min read
Enantioselective 1,2-Anionotropic Rearrangement of Acylsilane
through a Bisguanidinium Silicate Ion Pair Weidi Cao, Davin Tan, Richmond Lee and Choon-Hong Tan J. Am. Chem. Soc., 2018, 140, 1952-1955...
82 views0 comments


TCHLab
Nov 7, 20171 min read
Aerobic Oxidation of Benzylic sp3 C−H Bonds
through Cooperative Visible‐Light Photoredox Catalysis of N‐Hydroxyimide and Dicyanopyrazine Xinfei Liu, Lu Lin, Xinyi Ye, Choon‐Hong Tan...
57 views0 comments


TCHLab
Sep 16, 20171 min read
Organocatalytic Enantioselective Protonation for Photoreduction of
Activated Ketones and Ketimines Induced by Visible Light Lu Lin, Xiangbin Bai, Xinyi Ye, Xiaowei Zhao, Choon‐Hong Tan, and Zhiyong Jiang....
36 views0 comments


TCHLab
May 23, 20171 min read
Recent Advances in Enantioselective Brønsted Base Organocatalytic Reactions
Bo Teng, Wei Chun Lim and Choon-Hong Tan Synlett., 2017, 28, 1272-1277 Abstract: Enantioselective Brønsted base catalyzed reactions have...
57 views0 comments


TCHLab
Apr 5, 20172 min read
Phase-Transfer and Ion-Pairing Catalysis of Pentanidiums and Bisguanidiniums
Lili Zong and Choon-Hong Tan Acc. Chem. Res. 2017, 50, 842−856 Abstract: Catalysts accelerate biological processes and organic reactions...
91 views0 comments


TCHLab
Mar 9, 20172 min read
Preparation of Polydimethylsiloxane–Polyvinylidene Fluoride Composite Membranes for
Phenol Removal in Extractive Membrane Bioreactor Meng-Yi Jin, Yuan Liao, Chun Heng Loh, Choon-Hong Tan and Rong Wang Ind. Eng. Chem....
10 views0 comments


TCHLab
Jan 20, 20171 min read
Mechanistic insights for the photoredox organocatalytic fluorination of aliphatic carbons
by anthraquinone using time-resolved and DFT studies Kee, J. W.; Shao, H.; Kee, C. W.; Lu, Y.; Soo, H. S.; Tan, C.-H Catalysis Science &...
23 views0 comments


TCHLab
Dec 15, 20161 min read
Disulfide Bond-Containing Ajoene Analogues As
Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa Fong, July; Yuan, Mingjun;...
15 views0 comments


TCHLab
Nov 21, 20161 min read
Bisguanidinium dinuclear oxodiperoxomolybdosulfate ion pair-catalyzed enantioselective sulfoxidation
Lili Zong, Chao Wang, Adhitya Mangala Putra Moeljadi, Xinyi Ye, Rakesh Ganguly, Yongxin Li, Hajime Hirao and Choon-Hong Tan Nature Comms,...
39 views0 comments

![Highly chemo-, enantio-, and diastereoselective [4 + 2] cycloaddition](https://static.wixstatic.com/media/43e1f5_a8425633278145dabb5182ce8092afb6~mv2.jpg/v1/fill/w_367,h_230,fp_0.50_0.50,q_90,enc_auto/43e1f5_a8425633278145dabb5182ce8092afb6~mv2.webp)
TCHLab
Nov 1, 20161 min read
Highly chemo-, enantio-, and diastereoselective [4 + 2] cycloaddition
of 5H-thiazole-4-ones with N-itaconimides Shuai Qiu, Choon-Hong Tan and Zhiyong Jiang Beilstein J. Org. Chem., 2016, 12, 2293 - 2297...
18 views0 comments


TCHLab
Aug 24, 20161 min read
Visible light photocatalysis in chemoselective functionalization of
C(sp3)-H bonds enabled by organic dyes Guo Wei, Chanbasha Basheer, Choon-Hong Tan and ZhiyongJiang Tetrahedron Letters, 2016, 57, 3801 -...
14 views0 comments


TCHLab
Aug 22, 20161 min read
Guanidine-catalyzed asymmetric Strecker reaction:
modes of activation and origin of stereoselectivity Xue, Hansong; Tan, Choon-Hong and Wong, Ming Wah Canadian Journal of Chemistry 2016,...
23 views0 comments


TCHLab
Jul 22, 20161 min read
Pentanidium- and Bisguanidinium-Catalyzed Enantioselective Alkylations
Using Silylamide as Brønsted Probase Bo Teng, Wenchao Chen, Shen Dong, Choon Wee Kee, Dhika Aditya Gandamana, Lili Zong and Choon-Hong...
50 views0 comments


TCHLab
May 9, 20161 min read
Enantioselective Aerobic Oxidative C(sp3)–H Olefination of Amines via
Cooperative Photoredox and Asymmetric Catalysis Guo Wei, Chenhao Zhang, Filip Bureš, Xinyi Ye, Choon-Hong Tan, Zhiyong Jiang ACS...
11 views0 comments


TCHLab
May 6, 20161 min read
Enantioselective Sulfoxidation Catalyzed by a Bisguanidinium Diphosphatobisperoxotungstate Ion Pair
Xinyi Ye, Adhitya Mangala Putra Moeljadi, Kek Foo Chin, Prof. Dr. Hajime Hirao, Dr. Lili Zong and Prof. Dr. Choon‐Hong Tan Angew. Chem....
43 views0 comments


TCHLab
Aug 6, 20151 min read
Chiral Bicyclic Guanidine-Catalyzed Enantioselective Sulfenylation of
Oxindoles and Benzofuran-2(3H)-ones Lisha Huang, Jiangtao Li, Yan Zhao, Xinyi Ye, Yang Liu, Lin Yan, Choon-Hong Tan, Hongjun Liu and...
20 views0 comments


TCHLab
Aug 3, 20151 min read
Enantioselective Oxidation of Alkenes with KMnO4 Catalyzed by Chiral Dicationic Bisguanidinium
Chao Wang, Lili Zong and Choon-Hong Tan J. Am. Chem. Soc., 2015, 137, 10677–10682 Abstract: Chiral anion-controlled ion-pairing catalysis...
57 views0 comments


TCHLab
Jul 15, 20151 min read
Enantioselective Synthesis of Quaternary Carbon Stereocenters:
Addition of 3-Substituted Oxindoles to Vinyl Sulfone Catalyzed with Pentanidiums Dr. Lili Zong, Shubo Du, Kek Foo Chin, Dr. Chao Wang and...
27 views0 comments


TCHLab
Jul 7, 20151 min read
Enantioselective Synthesis of Dialkylated α-Hydroxy Carboxylic Acids through Asymmetric PTC
(PTC = Phase-Transfer Catalysis) Shaobo Duan, Sanliang Li, Xinyi Ye, Nuan-Nuan Du, Choon-Hong Tan and Zhiyong Jiang The Journal of...
33 views0 comments


TCHLab
May 14, 20151 min read
Mechanistic Insights into Bicyclic Guanidine-Catalyzed Reactions
from Microscopic and Macroscopic Perspectives Hansong Xue, Danfeng Jiang, Huan Jiang, Choon Wee Kee, Hajime Hirao, Takahiro Nishimura,...
18 views0 comments


TCHLab
Apr 30, 20151 min read
Bicyclic Guanidine Catalyzed Asymmetric Tandem Isomerization Intramolecular‐Diels–Alder Reaction:
The First Catalytic Enantioselective Total Synthesis of (+)‐alpha‐Yohimbine Dr. Wei Feng, Danfeng Jiang, Dr. Choon‐Wee Kee, Dr. Hongjun...
25 views0 comments
TCHLab
Oct 24, 20141 min read
Asymmetric Michael Addition of 5 H-Oxazol-4-ones to Vinyl Sulfones:
Stereoselective Synthesis of Monofluorinated Analogs of 2‐Tertiary Hydroxyl‐3‐Methyl‐Substituted Carboxylic Acidl Derivatives Qian Liu,...
19 views0 comments


TCHLab
Oct 18, 20141 min read
Selective Fluorination of Unactivated C-H bond via organo-photocatalysis
Choon Wee Kee, Ke Min Chan, Prof. Dr. Ming Wah Wong and Prof. Dr. Choon‐Hong Tan Chemical Communications, 2014, 50, 8211 – 8214 Abstract:...
14 views0 comments


TCHLab
Oct 18, 20141 min read
Selective Bromination of sp3 C-H Bonds by Organophotoredox Catalysis
Choon Wee Kee, Ke Min Chan, Prof. Dr. Ming Wah Wong and Prof. Dr. Choon‐Hong Tan Asian Journal of Organic Chemistry, 2014, 3, 536 – 544...
20 views0 comments


TCHLab
Sep 10, 20141 min read
Catalytic Enantioselective Alkylation of Sulfenate Anions to Chiral Heterocyclic Sulfoxides
Using Halogenated Pentanidium Salts Lili Zong, Xu Ban, Choon Wee Kee and Prof. Dr. Choon‐Hong Tan Angewandte Chemie International...
46 views0 comments


TCHLab
Jul 2, 20141 min read
Utilizing hydrogen sulfide as a novel anti-cancer agent
by targeting cancer glycolysis and pH imbalance Z.-W. Lee, X.-Y. Teo, Evon Y.-W. Tay, C.-H. Tan, T. Hagen, P. K. Moore and L.-W. Deng...
2 views0 comments


TCHLab
Jun 6, 20141 min read
Halogen-Bonding-Induced Hydrogen Transfer to C=N Bond with Hantzsch Ester
Wei He, Yi-Cen Ge and Choon-Hong Tan Organic Letters, 2014, 16, 3244 – 3247 Abstract: Several bidentate dihydroimidazolines were prepared...
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