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Full Publication List


  1. X. Zhang, E. C. X. Ang, Z. Yang, C. W. Kee and C.-H. Tan, Synthesis of chiral sulfinate esters by asymmetric condensation, Nature, 2022, 604, 298-303.


  1. X. Ye and C.-H. Tan, Enantioselective transition metal catalysis directed by chiral cations, Chemical Science, 2021, 12, 533 – 539.

  2. X. Zhang and C.-H. Tan, Stereospecific and stereoconvergent nucleophilic substitution reactions at tertiary carbon centers, Chem, 2021, 7, 1–36.

  3. X. Ban, Y. Fan, T.-K. Khoa, R. Lee, C. W. Kee, Z. Jiang and C.-H. Tan, Pentanidium-Catalysed Direct Assembly of Vicinal All-Carbon Quaternary Stereocenters through C(sp3)-C(sp3) Bond Formation, CCS Chemistry, 2021, 3, 2192-2200. 


  1. K. F. Chin, X. Ye, Y. Li, R. Lee, A. M. Kabylda, D. Leow, X. Zhang, E. C. X. Ang and C.-H. Tan, Bisguanidinium-Catalyzed Epoxidation of Allylic and Homoallylic Amines under Phase Transfer Conditions, ACS Catalysis, 2020, 10, 4, 2684 – 2691.  

  2. J. Ren, X. Ban, X. Zhang, S. M. Tan, R. Lee and C.-H. Tan, Kinetic and Dynamic Kinetic Resolution of Racemic Tertiary Bromides by Pentanidium-Catalyzed Phase-Transfer Azidation, Angewandte Chemie International Edition, 2020, 59, 9055-9058. 

  3. E. C. X. Ang, C.-H. Tan, Golden Jubilee of Singapore National Institute of Chemistry (1970-2020): Celebrating Its Partnership with Wiley-VCH. Angewandte Chemie International Edition, 2020, 59 (45), 19728 – 19731. 

  4. E. C. X. Ang, X. Ye, C.-H. Tan, Preparation of Asymmetric Phase-Transfer Catalyst, 1,4-Bis((4S,5S)-1,3-Bis(3,5-Di-Tert-Butylbenzyl)-4,5-Diphenylimidazolidin-2-Ylidene)Piperazine-1,4-Diium Chloride. Organic Syntheses, 2020, 97, 274 – 293.

  5. W. Chen, E. C. X. Ang, S. M. Tan, Z. Chua, J. Ren, Z. Yang, B. Teng, R. Lee, H. Lu, C.-H. Tan, Enantioselective Addition-Alkylation Of Α,Β-Unsaturated Carbonyls Via Bisguanidinium Silicate Ion Pair Catalysis. Journal of the American Chemical Society 2020, 142 (45), 19065 – 19070.


  1. X. Zhang, J. Ren, S. M. Tan, D. Tan, R. Lee, C.-H. Tan, Enantioconvergent Halogenophilic Nucleophilic Substitution (SN2X) Reaction, Science, 2019, 363, 400 – 404.

  2. Q. Li, X. Li, L. Ning, C.-H. Tan, Y. Mu, R. Wang, Hyperfast water transport through biomimetic nanochannels from peptide-attached (pR)-pillar[5]arene, Small., 2019, 15, 1804678.

  3. Y.-C. Gordon Ge, X.-Y. Cui, H. Jiang, J.-Y. Ren, Nicholas Lee, C.-H. Tan, Guanidine–Copper Complex Catalyzed Allylic Borylation for the Enantioconvergent Synthesis of Tertiary Cyclic Allylboronates, Angewandte Chemie International Edition, 2019, 58, 2382 – 2386.

  4. Nicholas Lee, D.S. Leow, C.-H. Tan, Enantiospecific and Enantioselective Brook Rearrangements, Asian Journal of Organic Chemistry, 2019, 8, 25 – 31. 

  5. July Fong, K. T. Mortensen, A. Nørskov, K. Qvortrup, L. Yang, C. H. Tan, T. E. Nielsen, M. Givskov, Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa, Frontiers in Cellular and Infection Microbiology, 2019, 8, 443.

  6. Valerie H. L. Wong, C.-H. Tan, Y. H. Lim, Copper-mediated [11C]Formylation of Amines using [11C]CO2 and radiosynthesis of 2-[11C]-Heterocycles, ChemComm., 2019, submitted.

  7. X.-Y. Cui, D. Leow, C.-H. Tan, Metal-Catalysed Reactions Enabled by Guanidine-Type Ligands, Organic and Biomolecular Chemistry, 2019, 17, 4689 – 4699.

  8. H.-C. Chou, D. Leow and C.-H. Tan, Recent Advances in Chiral Guanidine-Catalyzed Enantioselective Reactions, Asian Journal of Organic Chemistry, 2019, 14, 3803 – 3822. 


  1. W. Cao, D. Tan, R. Lee, C.-H. Tan, Enantioselective 1,2-Anionotropic Rearrangement of Acylsilane through Bisguanidinium Silicate Ion Pair, Journal of the American Chemical Society, 2018, 140, 1952 – 1955.

  2. M.-Y. Jin, Y. R. Liao, C.-H. Tan, R. Wang, Development of high performance nanofibrous composite membranes by optimizing polydimethylsiloxane architectures for phenol transport, Journal of Membrane Science, 2018, 549, 638 – 648.

  3. X.-Y. Cui, Y. Ge, H. Jiang, Davin Tan, Yunpeng Lu, Richmond Lee, C.-H. Tan, (Guanidine)copper Complex-Catalysed Dynamic Kinetic Allylic Alkynylation Under Biphasic Conditions, Journal of the American Chemical Society, 2018, 140, 8448 − 8455. (Highlighted by Synfacts 2018, 5, 14(09), 0949; contributors: Mark Lautens, Andrew Whyte)

  4. Y. Liang, D. Zeng, X. Huang, L. Chan, C. Mei, P. Feng, C.-H.Tan, T. Chen, Cancer-targeted Design of Bioresponsive Prodrug with Enhanced Cellular Uptake for Precise Cancer Therapy, Drug Delivery, 2018, 25, 1350 – 1361.

  5. M.-Y. Jin, Y. Liao, Y. Lin, C.-H. Tan, R. Wang, Development of Highly-Efficient ZIF-8@PDMS/PVDF Nanofibrous Composite Membrane for Phenol Removal in Aqueous-Aqueous Membrane Extractive Process, Journal of Membrane Science, 2018, 568, 121 – 133.

  6. Repurposing the anti-cancer drug cisplatin as an effective Pseudomonas aeruginosa infection control agent, M. Yuan, S. L. Chua, Yang Liu, D. I. Drautz-Moses, J. K. H. Yam, T. T. Aung, R. W. Beuerman, M. M. S. Salido, S. C. Schuster, C.-H. Tan, M. Givskov, L. Yang, T. E. Nielsen, Beilstein Journal of Organic Chemistry, 2018, 14, 3059 – 3069.


  1. J. Fong, M. Yuan, T. H. Jakobsen, D. Santos, M. M. Salido, S. L. Chua, L. Yang, C.-H. Tan, T. E. Nielsen, M. Givsgov, Disulfide bond-containing ajoene analogs as novel quorum sensing inhibitors of Pseudomonas aeruginosa, 2017, Journal of Medicinal Chemistry, 2017, 60, 215 – 227.

  2. J. W. Kee, H. Shao, C. W. Kee, Y. Lu, H. S. Soo, C.-H. Tan, Mechanistic insights for the photoredox organocatalytic fluorination of aliphatic carbons by anthraquinone using time-resolved and DFT studies, Catalysis Science & Technology, 2017, 7, 848 – 857.

  3. L. Zong, C.-H. Tan, Phase transfer and ion pairing catalysis of pentanidiums and bisguanidiniums, Accounts of Chemical Research, 2017, 50, 842 – 856.

  4. M. Jin, Y. Liao, C. H. Loh, C.-H. Tan, W. Rong, Preparation of PDMS-PVDF composite membranes for phenol removal in extractive membrane bioreactor, Industrial & Engineering Chemistry Research, 2017, 56, 3436 – 3445.

  5. X. Liu, L. Lin, X. Ye, C.-H. Tan, Z. Jiang, Aerobic Oxidation of Benzylic sp3 C−H Bond through Cooperative Visible Light Photoredox Catalysis of N-Hydroxyimide and Dicyanopyrazine, Asian Journal of Organic Chemistry, 2017, 6, 422 – 425.

  6. B. Teng, W. C. Lim C.-H. Tan, Recent Advances in Enantioselective Brønsted Base Organocatalytic Reactions, Synlett, 2017, 28, 1272 – 1277.

  7. L. Lin, X. Bai, X. Ye, X. Zhao, C.-H. Tan, Z. Jiang, Organocatalytic Enantioselective Protonation for Photoreduction of Activated Ketones and Ketimines Induced by Visible Light, Angewandte Chemie International Edition, 2017, 56, 13842 – 13846.


  1. W. Feng, D. Jiang, C.-W. Kee, H. Liu, C.-H. Tan, Bicyclic Guanidine Catalyzed Asymmetric Tandem-Isomerisation Intramolecular-Diels-Alder Reaction: The First Catalytic Enantioselective Total Synthesis of (+)-alpha-Yohimbine, Chemistry – An Asian Journal, 2016, 11, 390 – 394. (Highlighted by D. F. Taber, Org. Chem. Highlights 2016, December 26. URL:

  2. G. Wei, C. Zhang, F. Bures, X. Ye, C.-H. Tan, Z. Jiang, Enantioselective Aerobic Oxidative C(sp3)−H Olefination of Amines via Cooperative Photoredox and Asymmetric Catalysis, ACS Catalysis, 2016, 6, 3708 − 3712.

  3. X. Ye, A. M. P. Moeljadi, K. F. Chin, H. Hirao, L. Zong, C.-H. Tan, Bisguanidinium Diphosphatobisperoxotungstate Ion-pair Catalyzed Enantioselective Sulfoxidation, Angewandte Chemie International Edition, 2016, 55, 7101 – 7105.

  4. G. Wei, C. Basheer, C.-H. Tan, Z. Jiang, Visible light photocatalysis in chemoselective functionalization of C(sp3)-H bonds enabled by organic dyes, Tetrahedron Letters, 2016, 57, 3801 – 3809.

  5. B. Teng, W. Chen, S. Dong, C. W. Kee, A. G. Dhika, L. Zong, C.-H. Tan, Pentanidium- and Bisguanidinium-Catalyzed Enantioselective Alkylations Using Silylamide as Brønsted Probase, Journal of the American Chemical Society, 2016, 138, 9935 − 9940.

  6. S Qiu, C.-H. Tan, Z. Jiang, Highly Chemo-, Enantio-, and Diastereo-selective [4+2] Cycloaddition of 5H-thiazol-4-ones with N-Itaconimides, Beilstein Journal of Organic Chemistry, 2016, 12, 2293–2297.

  7. L. Zong, C. Wang, X. Ye, C.-H. Tan, Bisguanidinium Dinuclear Oxodiperoxomolybdosulfate [(μ2-SO4)Mo2O2(μ2-O2)2(O2)2]  Ion-Pair: Characterization and Application in Asymmetric Sulfoxidation,  Nature Communications, 2016, 7, 13455.

  8. H. Xue, C.-H. Tan, M. W. Wong, Guanidine-catalyzed Asymmetric Strecker Reaction: Modes of Activation and Origin of Stereoselectivity, Canadian Journal of Chemistry, 2016, 94, 1099 – 1108.


  1. H. Xue, D. Jiang, H. Jiang, C. W. Kee, H. Hirao, T. Nishimura, M. W. Wong, C.-H. Tan, Mechanistic Insights of Chiral Bicyclic Guanidine-catalyzed Enantioselective Reactions from Microscopic and Macroscopic Perspectives, Journal of Organic Chemistry, 2015, 80, 5745 − 5752.

  2. L. Zong, S. Du, K. F. Chin, C. Wang, C.-H. Tan, Enantioselective Synthesis of Quaternary Carbon Stereocenters: Addition of 3-Substituted Oxindoles to Vinyl Sulfone Catalyzed with Pentanidiums, Angewandte Chemie International Edition, 2015, 54, 9390 – 9393.

  3. S, Duan, S. Li, X. Ye, N.-N. Du, C.-H. Tan, Z. Jiang, Enantioselective Synthesis of Dialkylated α-Hydroxy Carboxylic Acids through Asymmetric Phase-Transfer Catalysis, Journal of Organic Chemistry, 2015, 80, 7770 − 7778.

  4. C. Wang, L. Zong, C.-H. Tan, Enantioselective Oxidation of Alkenes with Potassium Permanganate Catalyzed by Chiral Dicationic Bisguanidinium, Journal of the American Chemical Society, 2015, 137, 10677 – 10682 (Highlighted by ACS Select Virtual Issue on Organocatalysis).

  5. L. Huang, J. Li, Y. Zhao, X. Ye, Y. Liu, L. Yan, C.-H. Tan, H. Liu, Z. Jiang, Chiral Bicyclic Guanidine−Catalyzed Enantioselective Sulfenylation of Oxindoles and Benzofuran-2(3H)-ones, Journal of Organic Chemistry, 2015, 80, 8933 − 8941.


  1. Z. Song, M. Y. Ng, Z.-W. Lee, W. Dai, T. Hagen, P. K. Moore, D. Huang, L.-W. Deng, C.-H. Tan, Hydrogen Sulfide donors in research and drug development, Med. Chem. Commun., 2014, 5, 557–570.

  2. C. W. Kee, C.-H. Tan, Selective bromination of sp3 C–H bonds by organophotoredox catalysis, Asian Journal of Organic Chemistry, 2014, 3, 536 – 544. (25 Most Accessed Articles from Asian Journal of Organic Chemistry)

  3. W. Chen, Z. Jing, K. F. Chin, B. Qiao, Y. Zhao, L. Yan, C.-H.-Tan, Z. Jiang, Catalytic asymmetric conjugate addition of mercaptans to β-substituted-β-trifluoromethyl oxazolidinone enoates: Access to chiral trifluoromethylated tertiary thioethers and thiols, Advanced Synthesis and Catalysis, 2014, 356, 1292 – 1300.

  4. B. Qabazard, L. Li, J. Gruber, L. F. Ng, S. D. Kumar, P. Rose, C.-H. Tan, B. W. Dymock, F. Wei, S. Swain, B. Halliwell, S. R. Sturzenbaum and P. K. Moore,, Hydrogen sulfide is an endogenous regulator of ageing in Caenorhabditis elegans, Antioxidants & Redox Signaling, 2014, 20, 2621 – 2630.

  5. C. W. Kee, K. F. Chin, M. W. Wong, C.-H. Tan, Selective fluorination of unactivated C-H bond via organo-photocatalysis, Chemical Communications, 2014, 50, 8211 –  8214.

  6. W. He, Y. Ge, C.-H. Tan, Halogen bonding induced transfer hydrogenation reactions using Hantzsch ester, Organic Letters, 2014, 16, 3244 − 3247.

  7. Z. Jing, J. Liu, K. F. Chin, W. Chen, C.-H. Tan, Z. Jiang, Chiral bicylic guanidine-catalyzed conjugate addition of α-fluoro-β-ketoesters to cyclic enones, Australian Journal of Chemistry, 2014, 67, 1119 – 1123.

  8. Z.-W. Lee, X.-Y. Teo, Evon Y.-W. Tay, C.-H. Tan, T. Hagen, P. K. Moore, L.-W. Deng, Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalance, 2013, British Journal of Pharmacology, 2014, 171, 4322 – 4336.

  9. L. Zong, X. Ban, C.W. Kee, C.-H. Tan, Catalytic enantioselective alkylation of sulfenate anions to chiral heterocyclic sulfoxides using halogenated pentanidiums, Angewandte Chemie International Edition, 2014, 53, 11849 – 11853. (Highlighted by Synfacts 2014, 10, 1322; contributors: Benjamin List, Mattia Riccardo Monaco; Selected by Matteo Zanda, Synform editor to be include in the Feb 2015 issue of Synform as a Synstory)

  10. Q. Liu, B. Qiao, K. F. Chin, C.-H. Tan, Z. Jiang, Asymmetric Michael addition of 5 H-oxazol-4-ones to vinyl sulfones: Stereoselective synthesis of monofluorinated analogs of 2-tertiary hydroxyl-3-methyl-substituted carboxylic acid derivatives, Advanced Synthesis and Catalysis., 2014, 356, 3777 – 3783.


  1. Y. C. Teo, Y. Pan, C.-H. Tan, Organic dye photocatalyzed in-situ generation of acylnitroso for Ene reactions, ChemCatChem, 2013, 5, 235 – 240.

  2. Z. Han, W. Yang, C.-H. Tan, Z. Jiang, Organocatalytic asymmetric Mannich reactions of 5H-oxazol-4-ones: Highly enantio- and diastereoselective synthesis of chiral α-alkyl isoserine derivatives, Advanced Synthesis and Catalysis, 2013, 355, 1505 – 1511.

  3. Z. Liu, Y. Han, L. Li, H. Lu, X. Li, M. Shirhan, M. T. Peh, L. Xie, Y. Tang, S. Zhou, X. Wang, Q. Chen, W. Dai, C.-H. Tan, P. K. Moore, Y. Ji, The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E-/- knockout mice, British Journal of Pharmacology, 2013, 169, 1795 – 1809.

  4. L. Chen, C. S. Chao, Y. Pan, S. Dong, Y. C. Teo, J. Wang, C.-H. Tan, Amphoteric methyleneamino synthon through organic dye catalyzed-decarboxylative aminoalkylation, Organic and Biomolecular Chemistry, 2013, 11, 5922 – 5925.

  5. L. Yan, Z. Han, B. Zhu, C. Yang, C.-H. Tan, and Z. Jiang, Asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates with α-fluoro-β-keto esters, Beilsten Journal of Organic Chemistry, 2013, 9, 1853 – 1857.

  6. W. Chen, W. Yang, F. Zhao, L. Yan, C.-H. Tan, Z. Jiang, Bicyclic guanidinium-catalyzed enantioselective phase-transfer alkylation: Comprehensive access to pyrroloindolines and furoindolines, Chemical Communications, 2013, 49, 9854 – 9856.

  7. C. Yang, W. Chen, W. Yang, B. Zhu, L. Yan, C.-H. Tan, and Z. Jiang, Bicyclic-guanidine-catalyzed asymmetric Michael addition of 3-substituted oxindoles to 2-cyclopentenone, Chem. Asian J., 2013, 8, 2960 – 2964.

  8. C. Wang, Cindy M. T. Goh, S. Xiao, W. Ye, C.-H. Tan, Enantioselective protonation catalyzed by chiral Brønsted bases, Journal of Synthetic Organic Chemistry Japan, 2013, 71, 1145 – 1151.


  1. Y. Zhao, Y. Pan, S.-B. D. Sim, C.-H. Tan, Enantioselective organocatalytic fluorination organofluoro nucleophiles, Organic and Biomolecular Chemistry, 2012, 10, 479 – 485. (Invited)

  2. J. Wang, J. Chen, C. W. Kee, C.-H. Tan, Bicyclic guanidine-catalyzed enantiodivergent γ-selective asymmetric allylic amination, Angewandte Chemie International Edition, 2012, 51, 2382 – 2386.

  3. W. Yang, D. Tan, R. Lee, L. Li, Y. Pan, K.-W. Huang, C.-H. Tan, Z. Jiang, Catalytic diastereoselective tandem conjugate addition-elimination reaction of Morita-Baylis-Hillman C-adducts via C–C bond cleavage, Chemistry - An Asian Journal, 2012, 7, 771 – 777.

  4. Y. Zhao, X. Lim, Y. Pan, L. Zong, C.-H. Tan, K.-W. Huang, Asymmetric H/D exchange reactions of fluorinated aromatic ketones, Chemical Communications, 2012, 48, 5479 – 5481.

  5.  L. Li, W. Chen, W. Yang, Y. Pan, H. Liu, C.-H. Tan, Z. Jiang, Bicyclic guanidine-catalyzed asymmetric Michael additions of 3-benzyl-substituted oxindoles to N-maleimides, Chemical Communications, 2012, 48, 5124 – 5126.

  6. K. S. Goh, C.-H. Tan, Metal-free Pinnick-type oxidative amidation of aldehydes, RSC Advances, 2012, 2, 5536 – 5538.

  7. B. Cho, C.-H. Tan, M.-W. Wah, Origin of asymmetric induction in bicyclic guanidine-catalyzed thio-Michael reaction: A bifunctional mode of Lewis acid-Brønsted acid activation, Journal of Organic Chemistry, 2012, 77, 6553 − 6562.

  8. W. Yang, L. Li, Y. Pan, H. Liu, Y. Yang, L. Yan, C.-H. Tan, Z. Jiang, Direct Asymmetric allylic alkenylation of N-itaconimides with Morita-Baylis-Hillman carbonates, Journal of Organic Chemistry, 2012, 77, 6600 − 6607.

  9. S. Wang, C. T. Nai, X.-F. Jiang, Y. Pan, C.-H. Tan, M. Nesladek, Q.-H. Xu, K. P. Loh, Graphene oxide-polythiophene hybrid with broadband absorption and photocatalytic properties, The Journal of Physical Chemistry Letters, 2012, 3, 2332 − 2336.

  10. W. Zhang, D. Tan, R. Lee, G. Tong, W. Chen, K.-W. Huang, C.-H. Tan, Z. Jiang, Highly enantio- and diastereoselective synthesis of γ,γ-butenolide-substituted α- and β-stereogenic amides via direct vinylogous Michael addition, Angewandte Chemie International Edition, 2012, 51, 10069 – 10073 (Highlighted by, Tristen Lambert;

  11. Y. Yang, F. Moinodeen, W. Chin, T. Ma, Z. Jiang, C.-H. Tan, Phase transfer pentanidium-catalyzed enantioselective a-hydroxylation of oxindole with molecular oxygen, Organic Letters, 2012, 14, 4762–4765. (Highlighted by, Tristen Lambert;


  1. Y. Zhao, Y. Pan, H. Liu, Y. Yang, Z. Jiang, K.-W. Huang, C.-H. Tan, a-Fluorinated aromatic ketone as nucleophile in asymmetric organocatalytic C-C and C-N bonds formation reactions: A facile route to the construction of fluorinated quaternary stereogenic carbon centers, Chemistry - An European Journal, 2011, 17, 3571 – 3574.

  2. T. Ma, X. Fu, C. W. Kee, L. Zong, Y. Pan, K.-W. Huang, C.-H. Tan, Pentanidium catalyzed enantioselective phase transfer conjugate addition reactions, Journal of the American Chemical Society, 2011, 133, 2828 – 2831. (Highlighted by Synfacts 2011, 5, 0556-0556; contributors: Benjamin List, Saihu Liao)

  3. Y. Zhang, C. W. Kee, Richmond Lee, X. Fu, Julian Y.-T. Soh, Esther M. F. Loh, K.-W. Huang and Choon-Hong Tan, C.-H. Tan, Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines, 2010, Chemical Communications, 47, 3897 – 3899.

  4. B. Cho, C.-H. Tan, M.-W. Wah, Sequential catalytic role of bifunctional bicyclic guanidine in asymmetric Phospha-Michael reaction, Organic and Biomolecular Chemistry, 2011, 9, 4550 – 4557.

  5. Y. Pan, C.-H. Tan, Catalytic decarboxylative reactions, a biomimetic approach inspired from polyketides biosynthesis, Synthesis, 2011, 13, 2044 – 2053. (Invited)

  6. Z. W. Lee, J. Zhou, C.-S. Chen, Y. Zhao, C.-H. Tan, Ling Li, P. K. Moore, L.-W. Deng, The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo, PLoS ONE, 2011, 6, e21077.

  7. X. Fu, C.-H. Tan, Mechanistic considerations of guanidines-catalyzed reactions, 2010, Chemical Communications, 2011, 47, 8210 – 8222. (Invited)

  8. W. Yang, X. Wei, Y. Pan, Richmond Lee, B. Zhu, H. Liu, L. Yan, K.-W. Huang, C.-H. Tan, Z. Jiang, Highly enantio- and diastereoselective synthesis of β-Methyl-γ-Monofluoro-Methyl substituted alcohols, Chemistry - An European Journal, 2011, 17, 8066 – 8070 (Designated as VIP – Very Important Paper).

  9. Y. Pan, C. W. Kee, Z. Jiang, T. Ma, Y. Zhao, Y. Yang, H. Xue, C.-H. Tan, Expanding the utility of Brønsted base catalysis: Biomimetic enantioselective decarboxylative reactions, Chemistry - An European Journal, 2011, 17, 8363 – 8370.

  10. B. Nugraha, X. Hong, X. Mo, L. Tan, W. Zhang, P.-M. Chan, C. H. Kang, Y. Wang, L. T. Beng, W. Sung, D. Choudhury, J. M. Rubens, M. McMillian, J. Silva, S. Dallas, C.-H. Tan, Z. Yue, Hanry Yu, Galactosylated cellulosic sponge for multi-well drug safety testing, Biomaterials, 2011, 32, 6982 – 6994.

  11. B. Zhu, L. Yan, Y. Pan, R. Lee, H. Liu, Z. Han, K.-W. Huang, C.-H. Tan, Z. Jiang, Enantioselective Lewis Base-catalyzed highly enantioselective allylic hydroxylation of Morita-Baylis-Hillman carbonates with water, Journal of Organic Chemistry, 2011, 76, 6894 – 6900.

  12. Y. L. Quek, C.-H. Tan, J. Bian, D. Huang, Air oxidation of HS- catalyzed by an mixed-valence diruthenium complex, an near-IR probe for HS- detection, Inorganic Chemistry, 2011, 50, 7379 – 7381.

  13. Y. Pan, C. W. Kee, L. Chen and C.-H. Tan, Dehydrogenative coupling reactions catalysed by Rose Bengal using visible light irradiation, Green Chemistry, 2011, 13, 2682 – 2685.

  14. F. Zhao, W. Zhang, Y. Yang, Y. Pan, W. Chen, H. Liu, L. Yan, C.-H. Tan, Z. Jiang, Synthesis of sulfur-substituted α-stereogenic amides and ketones: Highly enantioselective Sulfa-Michael Addition (SMA) of 1,4-dicarbonyl but-2-enes, Advanced Synthesis and Catalysis, 2011, 353, 2624 – 2630.

  15. Y. Pan, S. Wang, C. W. Kee, E. Dubuisson, K. P. Loh, and C.-H. Tan, Graphene Oxide and Rose Bengal: Oxidative C-H functionalization of tertiary amines using visible light, Green Chemistry, 2011, 13, 3341 – 3344.


  1. R. Lee, Y. Yang, G. K. Tan, C.-H. Tan, K.-W. Huang. A novel heteroleptic paddlewheel diruthenium bicyclic guanidinate complex: Synthesis, structure, and scope, Dalton Transactions, 2010, 39, 723 – 725.

  2. S. Huang, J. H. Chua, W. S. Yew, J. Sivaraman, P. K. Moore, C.-H. Tan, L.-W. Deng. Site-directed mutagenesis on human Cystathionine-gamma-lyase reveals insights into the modulation of H2S production, Journal of Molecular Biology, 2010, 396, 708 – 718.

  3. Y. Pan, Y. Zhao, T. Ma, Y. Yang, H. Liu, Z. Jiang, C.-H. Tan, Enantioselective synthesis of a-fluorinated b-amino acid derivatives via asymmetric Mannich reaction and selective decarboxylation/deacylation reactions, Chemistry - An European Journal, 2010, 16, 779 – 782.

  4. M. Whiteman, L. Li, P. C. Rose, C.-H. Tan, D. Parkinson, Philip K. Moore, The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages, Antioxidant and Redox Signaling, 2010, 12, 1147 – 1154.

  5. H. Liu, W. Feng, Y. Zhao, D. Leow, Y. Pan, C.-H. Tan, Organic dye photocatalyzed α-oxyamination through irradiation with visible light, Green Chemistry, 2010, 12, 953 – 956.

  6. D. Leow, C.-H. Tan, Catalytic reactions of chiral guanidines and guanidinium Salts, Synlett, 2010, 1589 – 1605. (Invited)

  7. X. Mo, Q. Li, L. Wai Y. L., B. Zheng C. H. Kang, B. Nugraha, Z. Yue, R. R. Jia, H. X. Fu, D. Choudhury, T. Arooz, J. Yan, C. T. Lim, S. Shen, C.-H. Tan, Hanry Yu, Rapid construction of mechanically-confined multi-cellular structures using dendrimeric intercellular linker, Biomaterials, 2010, 31, 7455 – 7467.

  8. J. Wang, H. Liu, Y. Fan, Y. Yang, Z. Jiang, C.-H. Tan Bicyclic guanidine-catalyzed direct asymmetric allylic addition of N-aryl alkylidene-succinimides, Chemistry - An European Journal, 2010, 16, 12534 – 12537.

  9. H. Liu, W. Feng, D. Leow, W.-T. Loh, C.-H. Tan, Brønsted-base catalyzed tandem isomerization-Michael reactions of alkynes: The synthesis of oxacycles and azacycles, 2010, Advanced Synthesis and Catalysis, 352, 3373 – 3379.


  1. D. Leow and C.-H. Tan, Chiral guanidines catalyzed enantioselective reactions, Chemistry - An Asian Journal, 2009, 4, 488 – 507. (Invited, Most accessed articles 6/2008–5/2009, Top 20 most cited article in Chem. Asian. J.)

  2. Z. Jiang, Y. Yang, Y. Pan, Y. Zhao, H. Liu and C.-H. Tan, Synthesis of α-stereogenic amides and ketones by enantioselective conjugate addition of 1,4-dicarbonyl but-2-enes, Chemistry - An European Journal, 2009, 15, 4925 – 4930.

  3. R. Lee, X. Lim, T. Chen, G. K. Tan, C.-H. Tan and K.-W. Huang. Selective formation of bicyclic guanidinium chloride complexes: Implication of the bifunctionality of guanidines. Tetrahedron Letters, 2009, 50, 1560 – 1562.

  4. Julian Y.-T. Soh, C.-H. Tan, Amino-indanol catalyzed enantioselective reactions of 3-hydroxy-2-pyridones, Journal of the American Chemical Society, 2009, 131, 6904 – 6905. (Highlighted by Synfacts 2009, 7, 0792-0792; contributors: Benjamin List, Saihu Liao)   

  5. H. Liu, D. Leow, C.-H. Tan, Enantioselective synthesis of chiral allenoates by guanidine-catalyzed isomerization of alkynoates, Journal of the American Chemical Society, 2009, 131, 7212 – 7213. (Highlighted by Synfacts 2009, 7, 0794-0794; contributors: Benjamin List, Steffen Müller)

  6. Z. Jiang, Y. Pan, Y. Zhao, T. Ma, R. Lee, Y. Yang, K.-W. Huang, M. W. Wong and C.-H. Tan, Synthesis of chiral quaternary C-F bond through highly enantioselective and diastereoselective guanidine-catalyzed addition of fluorocarbon nucleophiles, Angewandte Chemie International Edition, 2009, 48, 3627 – 3631. (Designated by Editors as Hot paper)

  7. Q. Sun, R. Collins, S. Huang, L. Holmberg-Schiavone, G. S. Anand, C.-H Tan,  S. van-den-Berg, L.-W. Deng, P. K. Moore, T. Karlberg and J. Sivaraman. Structures of human cystathionine -gamma-Lyase reveal new insights into the mechanism of H2S production, Journal of Biological Chemistry, 2009, 284, 3076 – 3085.

  8. L. Li, M. Salto-Tellez, C.-H. Tan, M. Whiteman, P. K. Moore. GYY4137, A novel hydrogen sulfide releasing molecule, protects against endotoxic shock in the rat, Free Radical Biology & Medicine, 2009, 47, 103 – 113.

  9. T. Zhou, X. Li, M. T. T. Ng, Y. Wang, N. M. Quek, J. Luo, W. Yuan, C.-H. Tan, H. Zeng, T. Li. Synthesis and characterization of circular structures of i-Motif tagged with Fluoresceins Bioconjugate Chemistry, 2009, 20, 644 – 647.

  10. X. Fu, W.-T. Loh, Y. Zhang, T. Chen, H. Liu, J. Wang, and C.-H. Tan, Chiral guanidinium salt catalyzed enantioselective Phospha-Mannich reactions, Angewandte Chemie International Edition, 2009, 2009, 40, 7387 – 7390. (Highlighted by Synfacts 2009, 11, 1281-1281; contributors: Benjamin List, Lars Ratjen)

  11. S. Lin, D. Leow, K.-W. Huang, C.-H. Tan. Enantioselective protonation of itaconimides with thiols and insights into the rotational kinetics of the axially chiral C–N bond, Chemistry An Asian Journal, 2009, 4, 1741 – 1744.


  1. J. Shen and C.-H Tan, Brønsted-Acid and Brønsted-Base catalyzed Diels–Alder reactions, Organic and Biomolecular Chemistry, 2008, 6, 3229 – 3236. (Invited)

  2. H. Liu, Y. Pan and C.-H. Tan, Sodium nitrite (NaNO2) catalysed iodo-cyclisation of alkenes and alkynes using molecular oxygen. Tetrahedron Letters, 2008, 49, 4424 – 4426.

  3. D. Leow, S. Lin, S. K. Chittimalla, X. Fu and C.-H. Tan, Enantioselective protonations catalyzed by chiral bicyclic guanidine, Angewandte Chemie International Edition English, 2008, 47, 5641 – 5645. (Highlighted by Synfacts 2008, 9, 0933-0933; contributors: Benjamin List, Frank Lay)

  4. J. Xu, X. Fu, R. Low, Y.-P. Goh, Z. Jiang and C.-H. Tan, Tandem conjugate Addition-Elimination reaction promoted by Chiral Pyrrolidinyl Sulphonamide (CPS), Chemical Communications, 2008, 5526 – 5528. (Highlighted by Douglass F. Taber, Org. Chem. Highlights 2009, August 10.)

  5. Z. Jiang, W. Ye, Y. Yang and C.-H. Tan, Rate acceleration of triethylamine-mediated guanidine-catalyzed enantioselective Michael reaction, Advanced Synthesis and Catalysis, 2008, 350, 2345 – 2351.

  6. J. Shen and C.-H. Tan, Anthrone-Derived NHPI analogues as catalysts in reactions using oxygen as an oxidant, Organic and Biomolecular Chemistry, 2008, 6, 4096 – 4098.

  7. Y. Wang, M. T. T. Ng, T. Zhou, X. Li, C.-H. Tan and T. Li, C3-Spacer-Containing circular oligonucleotides as inhibitors of Human Topoisomerase I. Bioorganic and Medicinal Chemistry Letters, 2008, 18, 3597 – 3602.

  8. L. Li, M. Whiteman, Y. Y. Guan, K. L. Neo, Y. Cheng, S. W. L, Y. Zhao, R. Baskar, C.-H. Tan and P. K. Moore, Characterisation of a novel, water soluble hydrogen sulfide releasing molecule (GYY4137): new insights into the biology of hydrogen sulphide, Circulation, 2008, 117, 2351 – 2360.

  9. S. M. Ong, C. Zhang, Y. C. Toh, S. H. Kim, H. L. Foo, C.-H. Tan, D. van Noort, S. Park and H. Yu, A gel-free 3D microfluidic cell culture system, Biomaterials, 2008, 29, 3237 – 3244.

  10. R.-S. Liu, V. Drozd, N. Bagkar, C.-C. Shen, I. Baginskiy, C.-H. Chen and C.-H. Tan. Direct white light phosphor based on metallorganic coordination extended networks for UV-light-emitting diodes Journal of the Electrochemical Society, 2008, 155 (6), P71-P73.

  11. D. Zhao, S.-M. Ong, Z. Yue, Y.-C. Toh, M. Khan, H. Yu, J.P. Chen, Z. Jiang, J. Shi and C.-H Tan, Dendrimer hydrazides as multivalent transient inter-cellular linkers, Biomaterials, 2008, 29, 3693 – 3702.

  12. C.-H Tan and J. Shen. 2,3,5,6-Tetrahydro-2,6-bis(phenylmethyl)-1H-imidazo[1,2-a]imidazole, Electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS), 2008, DOI: 10.1002/047084289X.rn00967. Article Online Posting Date: September 15, 2008. (Invited)


  1. Z. Jiang, Y. Zhang, W. Ye and C.-H. Tan, P-C Bond formation via direct and three-component conjugate addition catalyzed by 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD). Tetrahedron Letters, 2007, 48, 51 – 54.

  2. H. Liu and C.-H. Tan, Iodobenzene-catalysed iodolactonisation using sodium perborate monohydrate as oxidant. Tetrahedron Letters, 2007, 48, 8220 – 8222.

  3. X. Fu, Z. Jiang and C.-H. Tan, Bicyclic guanidine-catalyzed enantioselective Phospha-Michael reaction: Synthesis of chiral β-aminophosphine oxides and β-aminophosphines, Chemical Communications, 2007, 5058 – 5060.

  4. W. Ye, Z. Jiang, Y. Zhao, Serena L. M. Goh, D. Leow, Y.-T. Soh and C.-H. Tan. Chiral bicyclic guanidine as a versatile Brønsted base catalyst for the enantioselective Michael reactions of dithiomalonates and β-keto thioesters, Advanced Synthesis and Catalysis, 2007, 349, 2454 – 2458.

  5. S.M. Ong, L. He, N.T.T. Linh, Y.H. Tee, T. Arooz, G.P. Tang, C.H. Tan and Yu H. Transient inter-cellular polymeric linker. Biomaterials, 2007, 28, 3656 – 3667.


  1. W. Ye, D. Leow, Serena L. M. Goh, C.-T. Tan, C.-H. Chian and C.-H. Tan. Chiral bicyclic guanidines: a concise and efficient aziridine-based synthesis. Tetrahedron Letters, 2006, 47, 1007 – 1010.

  2. J. Xu, Y. Guan, S. Yang, Y. Ng, G. Peh and C.-H. Tan, Chiral imidazoline promoted asymmetric Baylis-Hillman reaction. Chemistry - An Asian Journal, 2006, 1, 724 – 729.

  3. J. Shen, T. T. Nguyen, Y.-P. Goh, W. Ye, X. Fu, J. Xu and C.-H. Tan, Chiral bicyclic guanidine catalyzed enantioselective reactions of anthrones. Journal of the American Chemical Society, 2006, 128, 13692 – 13693.


  1. W. Ye, J. Xu, C.T. Tan and C.H.Tan. 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) catalyzed Michael reactions. Tetrahedron Letters, 2005, 46, 6875 – 6878.

1995 – 2003

  1. R.B.Wang, C.M.Lim, C.H.Tan, B.K.Lim, K.Y.Sim and T.P.Loh. Ytterbium trifluoromethanesulfonate [Yb(OTf)3] promoted indium mediated allylation reactions of carbonyl-compounds in aqueous-media. Tetrahedron-Asymmetry, 1995, 6, 1825 – 1828.

  2. N.Srikanth, C.H.Tan, S.C.Ng, T.P.Loh, L.L.Koh and K.Y.Sim. Synthesis of heterocyclic analogues of tamoxifen as potential antiestrogens. Journal of Chemical Research-S, 1997, 8, 274 – 275; Journal of Chemical Research-M, 1997, 1828 – 1849.

  3. W.P.Hems, C.H.Tan, T.Stork, N.Feeder and A.B.Holmes. Intramolecular cyclisation of (Z)-N-4-alkenylnitrones and the effects of alkenyl substituents. Tetrahedron Letters, 1999, 40, 1393 – 1396.

  4. C.H.Tan, T.Stork, N.Feeder and A.B.Holmes. Stereoselective synthesis of the indolizidine core of the allopumiliotoxins. Tetrahedron Letters, 1999, 40, 1397 – 1400.

  5. Y.Kobayashi, C.H.Tan and Y.Kishi. Toward creation of a universal NMR database for stereochemical assignment: the case of 1,3,5-trisubstituted acyclic systems. Helvetica Chimica Acta, 2000, 83, 2562 – 2571.

  6. Y.Kobayashi, C.H.Tan and Y.Kishi. Stereochemical assignment of the C21-C38 portion of the Desertomycin/Oasomycin class of natural products via universal NMR databases: Prediction. Angewandte Chemie International Edition English, 2000, 39, 4279 – 4281.

  7. C.H.Tan, Y.Kobayashi and Y.Kishi. Stereochemical assignment of the C21-C38 portion of the Desertomycin/Oasomycin class of natural products via universal NMR databases: Proof. Angewandte Chemie International Edition English, 2000, 39, 4282–4284.

  8. C.H.Tan and A.B.Holmes. Total synthesis of allopumiliotoxin 323B'. Chemistry-A European Journal, 2001, 7, 1845 – 1854.

  9. Y.Kobayashi, C.H.Tan and Y.Kishi. Toward creation of a universal NMR databases for stereochemical assignment: Complete structure of the Desertomycin/Oasomycin class of natural products, Journal of the American Chemical Society, 2001, 123, 2076 – 2078.

  10. Y.Kobayashi, N.Hayashi, C.H.Tan and Y.Kishi. Toward the creation of NMR databases in chiral solvents for assignments of relative and absolute stereochemistry: Proof of concept. Organic Letters, 2001, 3, 2245 – 2248.D.H.Ryu, C.H.Tan and R.R.Rando. Synthesis of (+), (-)-Neamine and their positional isomers as potential antibiotics. Bioorganic and Medicinal Chemistry Letters, 2003, 13, 901 – 903.

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