Organocatalytic Enantioselective Protonation for Photoreduction of
- TCHLab
- Sep 16, 2017
- 1 min read
Activated Ketones and Ketimines Induced by Visible Light
Lu Lin, Xiangbin Bai, Xinyi Ye, Xiaowei Zhao, Choon‐Hong Tan, and Zhiyong Jiang.
Angewandte Chemie International Edition , 2017, 56(44), 13842-13846.
Abstract: The first catalytic asymmetric photoreduction of 1,2‐diketones and α‐keto ketimines under visible light irradiation is reported. A transition‐metal‐free synergistic catalysis platform harnessing dicyanopyrazine‐derived chromophore (DPZ) as the photoredox catalyst and a non‐covalent chiral organocatalyst is effective for these transformations. With the flexible use of a chiral Brønsted acid or base in H+ transfer interchange to control the elusive enantioselective protonation, a variety of chiral α‐hydroxy ketones and α‐amino ketones were obtained with high yields and enantioselectivities.
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