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Fluorinated Aromatic Ketones as Nucleophiles
Updated: Jun 9, 2019
in the Asymmetric Organocatalytic Formation of C-C and C-N Bonds: A Facile Route to the Construction of Fluorinated Quaternary Stereogenic Centers
Yujun Zhao, Yuanhang Pan, Hongjun Liu, Yuanyong Yang, Prof. Dr. Zhiyong Jiang and Prof. Dr. Choon‐Hong Tan
Chemistry - An European Journal, 2011, 17, 3571–3574.
Abstract: Highly enantioselective Mannich and α‐amination reactions have been successfully developed using α‐fluorinated aromatic ketones as fluorocarbon nucleophiles in the presence of a bicyclic chiral guanidine (see scheme; Ms=methanesulfonyl). This method is a simple and efficient approach to the construction of fluorinated quaternary stereogenic centers.
Paper download: https://doi.org/10.1002/chem.201003761
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