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Brønsted-acid and Brønsted-base catalyzed Diels–Alder reactions
- TCHLab
- Jun 4, 2008
- 1 min read
Juan Shen and Choon-Hong Tan
Org. Biomol. Chem., 2008, 6, 3229-3236
Abstract: The enantioselective Diels–Alder reaction is one of the most important reactions for the synthesis of complex molecules. It provides access to chiral six-membered carbocyclic compounds containing up to four stereogenic centers in a single step. Asymmetric catalysis in the Diels–Alder reaction has mainly been realized using chiral Lewis acids. In this perspective, we describe several cases of chiral Brønsted-acid and Brønsted-base catalyzed Diels–Alder reactions, providing an overview of this rapidly growing field.
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