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Bicyclic guanidine-catalyzed asymmetric Michael additions of
- TCHLab
- Mar 20, 2012
- 1 min read
3-benzyl-substituted oxindoles to N-maleimides
Lixin Li, Wenchao Chen, Wenguo Yang, Yuanhang Pan, Hongjun Liu, Choon-Hong Tan and Zhiyong Jiang
Abstract: A bicyclic guanidine-catalyzed Michael addition of 3-benzyl substituted oxindoles to N-maleimides has been developed to produce oxindole derivatives with a quaternary carbon chiral center at the 3-position in excellent yields and enantio- and diastereoselectivities. This is the first incorporation of N-benzylic α-branched succinimides into 3,3-disubstituted oxindoles.
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