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Asymmetric H–D exchange reactions of fluorinated aromatic ketones

Updated: Aug 14

Yujun Zhao, Xiaozhi Lim, Yuanhang Pan, Lili Zong, Wei Feng, Choon-Hong Tan and Kuo-Wei Huang

Chemical Communications, 2012, 48, 5479 – 5481


Abstract: Chiral bicyclic guanidine catalyzes the asymmetric H–D exchange reactions. Up to 30% ee was achieved. DFT calculations were employed to elucidate and explain the origin of the reaction's stereoselectivity.


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