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Tandem conjugate addition–elimination reaction promoted by chiral pyrrolidinyl sulfonamide (CPS)
- TCHLab
- Sep 24, 2008
- 1 min read
Junye Xu, Xiao Fu, Ruijuan Low, Yong-Peng Goh, Zhiyong Jiang and Choon-Hong Tan
Chem. Communi., 2008, 5526–5528. (Highlighted by Douglass F. Taber, Org. Chem. Highlights 2009, August 10).
Abstract: Chiral pyrrolidinyl sulfonamides have been found to promote the conjugate addition–elimination reaction between activated allylic bromides and 1,3-dicarbonyl compounds with high enantioselectivities and the highly functionalised products can be used to generate a variety of interesting enantiomerically pure compounds via simple transformations.
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