top of page
Search
TCHLab

Iodobenzene-catalysed iodolactonisation using sodium perborate monohydrate as oxidant

Hongjun Liu and Choon-Hong Tan

Tetrahedron Letters, 2007, 48, 8220–8222


Abstract: A convenient approach has been developed for iodolactonisation using iodobenzene as catalyst. The active reagent was generated in situ with tetra-n-butylammonium iodide (TBAI) and hypervalent iodine reagent, diacetoxyiodobenzene (PIDA). PIDA, in turn, was generated in situ using a catalytic amount of iodobenzene with sodium perborate monohydrate as the stoichiometric oxidant. A variety of olefinic acids including δ-pentenoic acids, δ-pentynoic acids and δ-hexynoic acid gave high yields of lactones using this methodology.


Paper download:


9 views0 comments

Comments


bottom of page