Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines

Yan Zhang, Choon Wee Kee, Richmond Lee, Xiao Fu, Julian Ying-Teck Soh, Esther Mun Foong Loh, Kuo-Wei Huang and Choon-Hong Tan

Chemical Communications, 47, 3897–3899.

Abstract: An amino-indanol derived chiral guanidine was developed as an efficient Brønsted base catalyst for the desymmetrization of meso-aziridines with both thiols and carbamodithioic acids as nucleophiles, which provided 1,2-difunctionalized ring-opened products in high yields and enantioselectivities.

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