Yifan Wang, Magdeline Tao Tao Ng, Tianyan Zhou, Xinming Li, Choon-Hong Tan and Tianhu Li. Bioorg. and Med. Chem. Lett., 2008,18, 3597–3602
Abstract: Some dumbbell-shaped circular oligonucleotides containing internal C3-spacers and Topo I-binding sites were designed and synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by some DNA repair enzymes.
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