Search
Bicyclic Guanidinium-Catalyzed Enantioselective Phase-Transfer Alkylation:
- TCHLab
- Aug 30, 2013
- 1 min read
direct access to pyrroloindolines and furoindolines
Wenchao Chen, Wenguo Yang, Lin Yan, Choon-Hong Tan and Zhiyong Jiang
Chemical Communications, 2013, 49, 9854 – 9856.
Abstract: Highly enantioselective phase-transfer alkylation of 3-substituted-2-oxindoles with activated bromomethanes is disclosed with a broad substrate scope by using bicyclic guanidinium as a catalyst and a Lewis acid as the co-catalyst. The alkylation adducts are versatile intermediates to accomplish the syntheses of pyrroloindolines and furoindolines.
Paper download:
Comments