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Bicyclic guanidine-catalyzed enantioselective phospha-Michael reaction:
- TCHLab
- Oct 1, 2007
- 1 min read
Synthesis of chiral β-aminophosphine oxides and β-aminophosphines
Xiao Fu, Zhiyong Jiang, and Choon-Hong Tan
Chem. Commun., 2007, 5058-5060
Abstract: Chiral bicyclic guanidine has been found to catalyze the phospha-Michael reactions of diaryl phosphine oxide to nitroalkenes with high enantioselectivities, offering a direct methodology to prepare chiral β-aminophosphine oxides and β-aminophosphines.
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