Bicyclic Guanidine‐Catalyzed Direct Asymmetric Allylic Addition of N‐Aryl Alkylidene‐Succinimides

Jianmin Wang, Hongjun Liu, Yitian Fan, Yuanyong Yang, Prof. Dr. Zhiyong Jiang, Prof. Dr. Choon‐Hong Tan

Chemistry - An European Journal, 2010, 16, 12534 – 12537.

Abstract: Enantio‐enriched maleimides and succinimides that can be used to prepare aza‐heterocycles with multiple chiral centers are obtained from the bicyclic guanidine‐catalyzed direct asymmetric allylic addition of N‐aryl alkylidene‐succinimides to imines. NMR studies and deuterium‐exchange experiments were used to study the intermediates in the reaction.

Paper download: https://doi.org/10.1002/chem.201002183