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1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) catalyzed Michael reactions

Updated: Jun 7, 2019

Weiping Ye, Junye Xu, Chin-Tong Tan, Choon-Hong Tan

Tetrahedron Letters , 2006, 47, 1007–1010 (Highlighted in ChemInform, 2006, 37, DOI: 10.1002/chin. 200620062.)



Abstract: 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD), a bicyclic guanidine base, has been found to be an excellent catalyst for Michael and Michael-type reactions. A wide variety of Michael donors and acceptors can participate in these reactions using 10–20 mol % of TDB. These reactions are mild, fast, easy to perform, produce excellent yields and can occur in several solvents without the need for strictly anhydrous conditions.


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